Adenoviral–mediated Hath1–EGFP gene transfer into guinea pig cochlea through intact round window membrane
نویسندگان
چکیده
منابع مشابه
Round Window Membrane and Delivery of Biologically Active Agents into the Cochlea
Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. The most feasible approach for a non invasive drug delivery to the inner ear is application of medication to the middle ear cavity on the promise that it will diffuse through the thin...
متن کاملGene Expression Pattern after Insertion of Dexamethasone-Eluting Electrode into the Guinea Pig Cochlea
A cochlear implant is an indispensable apparatus for a profound hearing loss patient. But insertion of the electrode entails a great deal of stress to the cochlea, and may cause irreversible damage to hair cells and related nerve structure. Although damage prevention effects of dexamethasone have been reported, long-term administration is difficult. In this study, we used a dexamethasone-elutin...
متن کاملQuantification of solute entry into cochlear perilymph through the round window membrane.
The administration of drugs to the inner ear via the round window membrane is becoming more widely used for both clinical and experimental purposes. The actual drug levels achieved in different regions of the inner ear by this method have not been established. The present study has made use of simulations of solute movements in the cochlear fluids to describe the distribution of a marker solute...
متن کاملPathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane.
OBJECTIVE To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO). STUDY DESIGN Comparative human temporal bone study. SETTING Tertiary academic medical center. SUBJECTS AND METHODS We compared 23 temporal bone specimens from 19 deceased donors with LO associated with the round window membrane (RW...
متن کاملA cationic nonselective stretch-activated channel in the Reissner's membrane of the guinea pig cochlea.
The Reissner's membrane (RM) separates in the mammalian cochlea the K(+)-rich endolymph from the Na(+)-rich perilymph. The patch-clamp technique was used to investigate the transport mechanisms in epithelial cells of RM freshly dissected from the guinea pig cochlea. This study shows a stretch-activated nonselective cationic channel (SA channel) with a linear current-voltage relationship (23 pS)...
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ژورنال
عنوان ژورنال: Journal of Otology
سال: 2008
ISSN: 1672-2930
DOI: 10.1016/s1672-2930(08)50003-1